Position Details
Position Information
| Recruitment/Posting Title |
Post-Doctoral Associate |
| Department |
SEBS-Plant Biology |
| Salary |
Commensurate With Experience |
| Benefits |
Rutgers offers a comprehensive benefit program to eligible employees. For details, please go to
http://uhr.rutgers.edu/benefits/benefits-overview. |
| Posting Summary |
A postdoctoral associate position is available in the Department of Plant Biology at Rutgers University in the laboratory of Dr. Nilgun Tumer to identify small molecule inhibitors against ricin toxin and Shiga toxin 2. Using fragment-based ligand discovery (
FBLD) with surface plasmon resonance (
SPR) we identified the first group of small molecules that bind at the ribosomal P-stalk binding site of ricin and Shiga toxin 2 and inhibit the catalytic activity of each toxin (Rudolph et al., 2024
ACS Infect Dis. 10:2814; Li et al., 2020,
ACS Infect. Dis. 6:1894-1905). We improved these compounds using structure-based design and obtained improved compounds, which inhibit the activity and cytotoxicity of ricin holotoxin in mammalian cells (McLaughlin et al., 2025,
J. Biol. Chem. in press; C; Rudolph et al., 2024
Bioorg Med Chem. 100:117614; Li, et. al, 2021
, J. Med. Chem. 64:15334-15348).
The successful candidate will work on
identifying inhibitors that inhibit the activity of ricin and Shiga toxin 2 by disrupting toxin-ribosome interactions. The postdoc will use fluorescence polarization-based competition assays to determine the affinity of the compounds and qRT-
PCR based activity assays to examine the inhibitory activity of small molecules against ricin and Shiga toxin 2 in cell-based assays. The postdoc should have experience with protein purification, fluorescence assays, and mammalian cell culture. Experience working with small molecule and peptide inhibitors is desirable.
The ideal candidate should have a Ph.D. in Biochemistry, Molecular Biology, Biophysics or a related field. The position is funded by an
NIH grant. |
| Position Status |
Full Time |
| Posting Number |
25FA0253 |
| Posting Open Date |
03/14/2025 |
| Posting Close Date |
|
Qualifications
| Minimum Education and Experience |
Ph.D. in Biochemistry, Molecular Biology, Biophysics or a related field. Experience with protein purification, fluorescence assays, and mammalian cell culture. Experience working with small molecule and peptide inhibitors is desirable. |
| Certifications/Licenses |
|
| Required Knowledge, Skills, and Abilities |
|
| Equipment Utilized |
|
| Physical Demands and Work Environment |
|
| Overview |
|
| Statement |
|
Posting Details
| Special Instructions to Applicants |
Interested applicants must apply online through
ROCS system of Rutgers University at
https://jobs.rutgers.edu/postings/246994
and upload CV, cover letter/research interests, PhD certification, and contact information for at least 4 references. Applications will be reviewed until the position is filled. |
| Quick Link to Posting |
https://jobs.rutgers.edu/postings/246994 |
| Campus |
Rutgers University-New Brunswick |
| Home Location Campus |
Cook (RU-New Brunswick) |
| City |
New Brunswick |
| State |
NJ |
| Location Details |
59 Dudley Road - Foran Hall, New Brunswick, NJ 08901 |
Pre-employment Screenings
All offers of employment are contingent upon successful completion of all pre-employment screenings. Immunization Requirements
Under Policy 100.3.1 Immunization Policy for Covered Individuals, if employment will commence during Flu Season, Rutgers University may require certain prospective employees to provide proof that they are vaccinated against Seasonal Influenza for the current Flu Season, unless the University has granted the individual a medical or religious exemption. Additional infection control and safety policies may apply. Prospective employees should speak with their hiring manager to determine which policies apply to the role or position for which they are applying. Failure to provide proof of vaccination for any required vaccines or obtain a medical or religious exemption from the University will result in rescission of a candidate's offer of employment or disciplinary action up to and including termination. Affirmative Action/Equal Employment Opportunity Statement
It is university policy to provide equal employment opportunity to all its employees and applicants for employment regardless of their race, creed, color, national origin, age, ancestry, nationality, marital or domestic partnership or civil union status, sex, pregnancy, gender identity or expression, disability status, liability for military service, protected veteran status, affectional or sexual orientation, atypical cellular or blood trait, genetic information (including the refusal to submit to genetic testing), or any other category protected by law. As an institution, we value diversity of background and opinion, and prohibit discrimination or harassment on the basis of any legally protected class in the areas of hiring, recruitment, promotion, transfer, demotion, training, compensation, pay, fringe benefits, layoff, termination or any other terms and conditions of employment. For additional information please see the Non-Discrimination Statement at the following web address: http://uhr.rutgers.edu/non-discrimination-statement |
Rutgers University
Apr 22, 2025