Scientist Cell Culture Development

Pharma Technical Cell and Gene Therapies (PTC) focuses on developing robust manufacturing processes and quality control systems to efficiently transform scientific ideas into products. PTC reliably delivers quality products to patients enrolled in clinical studies around the world. PTC excels by creating an engaging and inclusive environment where everyone can bring their skills and talents to developing innovative medicines.

The Opportunity:

As a Cell Culture Scientist, you will be responsible for developing, optimizing, and performing process development experiments to improve process performance, productivity, and product quality of gene therapy vectors produced by production processes. Utilizing systems including ambr250ht, bench-scale, and pilot-scale bioreactors, as well as small-scale chromatography and centrifugation systems, you will drive the development, optimization, and characterization of the upstream process for use in technology transfer and GMP manufacturing.

In this role, you will provide support to different functional groups within PTC and actively participate in cross-functional teams consisting of members from all areas of process development. You will author and review protocols, technical reports, scientific articles and contribute to regulatory submissions in support of clinical trials and licensure. Additionally, you will:

• Develop and execute process development experiments to support process lock and scale-up, technology transfer, and GMP manufacture.

• Execution of production batches for material generation of vectors to supply requirements of cross-functional colleagues.

• Evaluate, summarize, present, and document in-process and analytical data resulting from upstream process development experiments.

• Provide technical support of analytical testing and technology transfer activities.

• Author and review technical development documents and relevant sections of health authority filings.

• Provide hands-on, technical execution in the laboratory while providing mentorship to junior colleagues.

• Maintain timely and accurate lab records consistent with good documentation practices.

• Serve as a technical expert or representative and provide process knowledge and expertise to cross-functional teams.

Who You Are

• You possess a Bachelor's in Biochemistry, Biotechnology, Chemical Engineering or related field with 4+ years of industry experience; or a Master's degree in a relevant discipline with 1 year of industry experience; or a PhD in a relevant discipline with 0-2 years of industry/post doctoral experience.

• You have knowledge in the development of upstream process stages (seed train, bioreactor production and harvest) of therapeutic modalities, and practical expertise in the application of innovative technologies including bioreactor scaling, perfusion, transmembrane filtration, and dead-end filtration.

• You possess gene therapy (AAV) experience

• You are self-motivated, have excellent organization, oral and written communication skills, and have demonstrated skills to work both independently and as a collaborative team member.

• You have demonstrated experience presenting data and insights for various audiences.

• You thrive in a dynamic, fast-paced environment and excel at managing various responsibilities while consistently meeting deadlines.

Preferred Experience:

• Working knowledge of bioreactor operation (ambr250ht, bench-scale bioreactors) and data analysis.

• Working knowledge of documentation systems and electronic lab notebooks, along with best practices.

• Working knowledge of statistical methods and software (JMP), data analytics or multivariate analysis.

• Familiarity or working knowledge of programming languages such as R, Python or Javascript.

Relocation benefits are not approved for this posting.

The expected salary range for this position based on the primary location of Philadelphia, PA is $91,000 (min) - $130,000 (mid) - $169,000 (max). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed in this link.

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.