Computational Genomics Research Scientist

We are seeking a computational biologist with a strong track record of advancing biological discoveries through data analyses to join the Vertex Data and Computational Sciences (DCS) organization. In this role, you will leverage cutting edge computational biology to accelerate the development of transformative therapies for serious human diseases. As a member of cross-functional disease project teams, you will contribute to the development of novel therapies in areas including lung diseases and pain. You will design genomics and human genetic studies, develop and apply analytical methods, and interpret results that directly inform program strategy, target evaluation, and mechanistic understanding. You will also play a key role in innovating, evaluating, and applying state-of-the-art computational analyses to enable rapid, data-driven decisions. An independent and proactive approach, along with seamless cross-functional collaboration will be essential for success in this role.

This is a San Diego based, hybrid position requiring 3 days/week onsite.

Key responsibilities:

• Proactively collaborate with crossfunctional project teams as thecomputational biologyexpert toidentifykey scientific questionsthat can beaddressedthroughhuman genetics,genomics, sequencing, and computational analyses.
• Design andexecutestudiesacross diverse omics, including bulk RNAseq, wholegenome sequencing, singlecell RNAseq, spatial transcriptomics, and human genetics.
• Perform sophisticated computational analyses of internal and external datasets, integrating deep critical thinking, statistical rigor, domainexpertise, and best practices from the literature to generate actionable insights.
• Incorporate publicly available genomic resources (e.g.,GTEx,gnomAD,FinnGen, UK Biobank) to contextualize and interpret internal data.
• Distill complex analyses and scientific results intoclear presentations, includingkey take-home messages and recommendations for next steps to a broadaudience.
• Author study reports,white papers,andmanuscriptsto supportinternal decision-making andexternal communications includingregulatory filings.
• Partner withtheDCSmethod development teamtodevelop innovative methods andimprove usability, accuracy, and robustness ofexisting ones.

Knowledge and Skills: