Global Head Neuroscience Translational Medicine

Job Description Summary

Job Description

Novartis BioMedical Research (BR) is the innovation engine of Novartis. We collaborate across scientific and organization boundaries, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs from patients. Within BR, Translational Medicine (TM) is the clinical research arm and includes over 900 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application.

Within TM, TM Discovery & Profiling (TMDP) is a group of about 65 physicians and clinical researchers who drive that innovative science from discovery to the patient through the selection, profiling, and effective development of medicines. Translational Medicine Experts (TME's) oversee Phase 1 and 2 clinical trials to demonstrate proof of concept in patients, creating the case for drugs to proceed to late-stage development and registration. TME's are also responsible for Phase 3 clinical pharmacology and mechanistic studies. Overall, TM and NIBR deliver about half of the final drug dossier or label information.

As the Global Head TM Neuroscience, you will lead a team of TME's responsible for all early clinical development plans and studies through Proof of Concept, new disease indications, translational research and profiling activities, and clinical pharmacology studies for the Neuroscience Therapeutic Area. You will be a member of the global Translational Medicine Leadership Team, accountable for overall department goals, helping to lead continuous improvement across the department, and enhancing the culture of TM. You will also be a key bridge between NS Research and late phase development and commercial colleagues across the Neuroscience Franchise in Novartis.

Key responsibilities:

* Set, communicate and drive strategy for the NS Translational Medicine Therapeutic Area in alignment with the broader organization
* Be accountable for setting the biomarker strategy for your group
* Prioritize and allocate resources across the team to meet portfolio needs
* Co-chair the Disease Area Decision Board with the Research Disease Area Head to decide on targets, compounds, and indications to progress from preclinical ideas to clinical testing
* Deliver clear early development study outcomes for decisions on new compounds
* Collaborate with Development colleagues to agree on indications and on transitional development point criteria
* Support Translational Medicine Experts on Development teams after Proof-of-Concept to deliver clinical pharmacology and mechanistic studies
* Bring relevant internal and external opinion leaders together to consider the proposed approach to Clinical Proof-of-Concept
* Ensure seamless collaboration across Research, Translational Medicine, Development, and other relevant line functions in the development of drug candidates. Work closely and effectively with other TA TM Heads to foster collaborations and lead to cross-DA indication expansion PoC opportunities
* Foster strong external clinical collaborations to maintain state of the art clinical approaches
* Contribute senior level expertise to Strategic Alliances, Business Development and Licensing due diligence reviews for in licensing and out licensing opportunities
* Provide or review Translational Medicine input to meetings and interactions with Health Authorities
* Develop talent pipeline through recruitment activities and being a mentor, coach, and educational resource across Novartis responsible for quality of clinical protocols, study reports and submission documents

Essential Requirements:

Education:
* MD or MD/PhD, or MD with doctoral thesis in relevant field (Neurology or Neuroscience)
* Board certification in Neurology or related field. Subspecialty clinical training in Neurodegenerative disorders (preferred) or related subspecialty with appropriate Board Certification(s)

Languages:
* Fluent English, strong written and oral communication skills

Experience:

* Leadership position in pharmaceutical/biotech industry or academic medical center combining scientific and medical subspecialty skills, maintaining state-of-the-art clinical approaches and inspiring a culture of continuous improvement, innovation and quality.

* Significant clinical experience with patients with Neurological disease.

* Experience driving translational clinical research from first in human studies through proof of concept.

* Experience leading in a matrixed environment successfully supporting and influencing experts, scientists and project deliveries across many functions of Research, Development and Commercial

* Strategic thinker, used to creating major innovations, networking with leading investigators, presenting complex strategic issues in a clear and logical way and driving impactful outcomes

* Natural ability to manage people, and lead leaders of others; able to provide mentoring at the highest levels including those outside of your own scientific/clinical expertise.

* Strong program manager: excellent planning, prioritization, problem solving and organizational skills

* Resilient, energetic and enthusiastic; responding constructively to challenging new ideas and inputs

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Benefits and Rewards:

Read our handbook to learn about all the ways we'll help you thrive personally and professionally: Novartis Life Handbook

Commitment to Diversity and Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $298,400 to $447,600/annually however, while salary ranges are effective from 1/1/24 through 12/31/24; fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

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Salary Range

Skills Desired